1- Danesh Alborz University
2- Bu-Ali Sina University ,saeidshamlou9092@gmail.com
3- Imam Khomeini International University
2- Bu-Ali Sina University ,
3- Imam Khomeini International University
Abstract: (70 Views)
Introduction: The aim of this study was to determine the effect of combined exercise and consumption of grape seed extract on some factors of oxidative and antioxidant stress in postmenopausal women with type 2 diabetes.
Materials and Methods: The current study was conducted as a clinical trial in 80 women with type 2 diabetes, who were randomly divided into four groups (20 people): control, exercise, GSE supplement, exercise+ GSE supplement. The combined exercise protocol consisted of aerobic and strength training, which was performed for eight weeks (five days/week). GSE supplement was taken in the form of 200 mg capsules daily (morning and noon). Samples (five cc) were taken before and after eight weeks of interventions. In order to investigate intra-group and inter-group changes, two-way analysis of variance test, followed by Tukey's post hoc test, was used by SPSS version 25 (p≤0.05).
Results: The values of total antioxidant capacity (TAC) and serum glutathione reduction (GSH) in the GSE and exercise + GSE groups increased significantly compared to the control and exercise groups (p=0.001). Serum malondialdehyde (MDA) levels in the GSE group showed a significant decrease compared to the control and exercise groups (p=0.001).
Conclusion: It seems that the intervention of grape seed extract is more effective in reducing oxidative stress than combined exercise. The consumption of this extract alone, as well as with combined exercise, has a significant effect on increasing the total antioxidant capacity and reducing GSH (glutathione).
Materials and Methods: The current study was conducted as a clinical trial in 80 women with type 2 diabetes, who were randomly divided into four groups (20 people): control, exercise, GSE supplement, exercise+ GSE supplement. The combined exercise protocol consisted of aerobic and strength training, which was performed for eight weeks (five days/week). GSE supplement was taken in the form of 200 mg capsules daily (morning and noon). Samples (five cc) were taken before and after eight weeks of interventions. In order to investigate intra-group and inter-group changes, two-way analysis of variance test, followed by Tukey's post hoc test, was used by SPSS version 25 (p≤0.05).
Results: The values of total antioxidant capacity (TAC) and serum glutathione reduction (GSH) in the GSE and exercise + GSE groups increased significantly compared to the control and exercise groups (p=0.001). Serum malondialdehyde (MDA) levels in the GSE group showed a significant decrease compared to the control and exercise groups (p=0.001).
Conclusion: It seems that the intervention of grape seed extract is more effective in reducing oxidative stress than combined exercise. The consumption of this extract alone, as well as with combined exercise, has a significant effect on increasing the total antioxidant capacity and reducing GSH (glutathione).
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