Volume 26, Issue 2 (7-2026)
Iran J Diabetes Metab. 2026, 26(2): 170-181 |
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Fazayeli Rad B, Jamaladini F A, Etminan A, Gozashti M. Diabetic Nephropathy and the Risk of Cardiac Arrhythmia: Association between Macroalbuminuria and QTc Interval. Iran J Diabetes Metab. 2026; 26 (2) :170-181
URL: http://ijdld.tums.ac.ir/article-1-6498-en.html
URL: http://ijdld.tums.ac.ir/article-1-6498-en.html
1- Neurology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2- Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
3- Departments of Nephrology, Urology and Renal Transplantation, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
3- Departments of Nephrology, Urology and Renal Transplantation, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract: (118 Views)
Background: Diabetic nephropathy is a major complication of diabetes, linked to cardiovascular disorders. QTc interval prolongation on electrocardiography increases the risk of cardiac arrhythmias and sudden death. This study evaluated the relationship between diabetic nephropathy severity and QTc prolongation.
Methods: In this prospective cohort study, 180 patients with type 1 or type 2 diabetes at teaching hospitals of Kerman University of Medical Sciences were enrolled. Based on albuminuria, patients were classified into microalbuminuria (30–300 mg/g) and macroalbuminuria (>300 mg/g) groups. QTc was measured using a standard 12-lead electrocardiogram and corrected with Bazett’s formula. Demographic, clinical, and laboratory data were analyzed with appropriate statistical tests.
Results: Among 180 patients, 14(7.8%) had microalbuminuria and 166(92.2%) had macroalbuminuria. Mean age was 59.65 ± 10.59 years. QTc was significantly longer in the macroalbuminuria group compared with the microalbuminuria group (436.07 ± 39.97 vs. 411.64 ± 23.63 ms, p= 0.002). Albumin excretion rate showed a weak positive correlation with QTc (r=0.182, p= 0.016). Logistic regression revealed macroalbuminuria was associated with a 10.5- fold higher odds of abnormal QTc (95% CI: 1.33–82.79, p=0.026).
Conclusion: Macroalbuminuria, indicating advanced diabetic nephropathy, is significantly associated with QTc prolongation. Regular electrocardiographic monitoring in diabetic patients with macroalbuminuria is recommended for early detection of cardiac electrophysiological abnormalities and prevention of cardiovascular complications.
Keywords: Diabetic nephropathy, Macroalbuminuria, QTc interval, Cardiac arrhythmia, Diabetes mellitus
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